QIAGEN Clinical Insight (QCI) Interpret

• Dynamic candidate disease identification and phenotype network for confident clinical exome interpretation
• AMP- and ACMG-based variant classifications for every variant in over 70,000 phenotypes
• Weekly updated manually curated literature for all variants to increase diagnostic yield and avoid spending time researching variants of unknown significance
• Weekly updated clinical case information, therapeutic, prognostic, diagnostic evidence, including drug labels, recruiting clinical trials, practice guidelines, and clinical/functional studies
• Access to >25 databases, including HGMD, COSMIC, ClinVar, gnomAD, AFC

QCI Interpret is an evidence-based decision support software intended as an aid in the interpretation of variants observed in genomic sequencing data. Variant scientists and lab directors can confidently identify, prioritize and report on clinically relevant variants associated with hereditary cancer, sporadic cancer, inherited disorders, and rare and undiagnosed diseases without the time-consuming step of researching the latest publications and writing variant- and disease-specific evidence.

With over 2 decades of experience in clinical genomics interpretation in inherited diseases and oncology, QCI Interpret processes and interprets over 50,000 cases monthly and has interpreted more than 2.5 million samples for pathologists and lab directors.

QCI Interpret offers flexible and automatable interpretation workflows, powered by superior structured content in the QIAGEN Knowledge Base.
The application delivers content for interpretation of small variants such as SNVs, indels, duplications, frameshifts, exon level and larger copy number changes, fusions, rearrangements, TMB and MSI.
With QCI Interpret, you can reduce hands-on time with configurable and automatable NGS interpretation workflows. Plus, you can access preconfigured, ready-to-use workflows for QIAGEN and commercial NGS panels. The software also lets you customize your lab’s specific reporting policies to automate variant reporting and drug and trial selection, and you can leverage a feature-rich API to integrate with your LIMS to scale-up your case processing.

QCI Interpret is designed to augment in-house expertise by providing you with all of the content necessary to confidently identify disease causing or actionable variants and manually generate the report whereas the QCI API enables you to integrate content into your existing workflows for further processing.