Next-generation sequencing

Deciphering the role of miRNAs

Overview

miRNAs are small but mighty, playing a significant role in gene expression regulation. There’s mounting evidence of their potential as disease biomarkers, which has driven extraordinary developments in cancer, metabolic and disease research. However, miRNA profiling research is often hindered by low RNA amounts and high levels of inhibitors, especially in biofluid samples. This has triggered a demand for dedicated solutions optimized for miRNA research – from high-quality miRNA extraction to efficient miRNA sequencing for miRNA expression insights. Advance your miRNA research by partnering with QIAGEN and benefitting from our high-performance miRNA solutions and expertise.

Featured success story

Scientist in the laboratory
Lourdes Chacon, MD
Assistant Director, Biorepository Core, Texas Heart Institute
Getting to the heart of miRNA profiling

Deciphering differential gene expression can unravel novel insights into the complex mechanisms at play in various diseases. Differential miRNA expression analysis from biorepository samples is a key component of the research conducted at the Texas Heart Institute (THI). Discover how researchers at THI are using QIAGEN’s miRNA-seq solution for analyzing miRNA expression in plasma-derived exosomes from lung transplanted patients.

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Product details

QIAseq miRNA
Low-input, high-throughput, gel-free miRNA-seq with integrated data analysis
Eliminate PCR bias and adapter dimers by adopting a gel-free approach for miRNA-seq library prep. Our miRNA-seq solution works with just 1 ng input. Looking to increase throughput? QIAseq miRNA Library Kits utilize 768 unique dual indices (UDIs), which means you can now perform high-throughput miRNA-seq on Illumina NovaSeq instruments without any fear of index hopping or compromising data quality. Built-in data analysis allows you to seamlessly go from generating miRNA-seq data to achieving gene expression insights.
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Go from miRNA-seq to gene expression insights with ease
Struggling to make sense of your miRNA-seq data? Take the stress out of data analysis and fast-track your path to gene expression insights with the new RNA-seq Analysis Portal. Designed for biologists and fully integrated with GeneGlobe, this intuitive, web-based solution is now included with QIAseq RNA-seq and miRNA-seq kits. Simply upload your sequence files into the RNA-seq Analysis Portal, start your analysis and go from FASTQ files to focused insights into the top 10 canonical pathways, upstream regulators and diseases using powerful IPA knowledge bases.
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Resources

Check out the webinars
Ryan Farr, SARS-CoV-2, miRNA, webinar, teaser
Altered microRNA expression in COVID-19 patients accurately identifies SARS-CoV-2 infection

Speaker: Ryan Farr, Ph.D., Research Scientist, Host Response Team, Health and Biosecurity (H&B) at the Australian Centre for Disease Preparedness
(ACDP), CSIRO

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Characterization of plasma-derived exosome miRNA and mRNA from patients with primary graft dysfunction after lung transplantation

Speaker: Lourdes Chacon-Alberty, M.D., MCTM Assistant Director of the Biorepository, Texas Heart Institute, Houston, Texas, USA.

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Key publications

Services

Enterprise Genomics Solutions, scientist taking notes, looking at a tube, result
Explore the miRNA NGS Seq Service

Take advantage of our high-performance chemistry and renowned expertise. Partner with Genomic Services to take your miRNA research to the next level. From miRNA-specific isolation and library prep through to data analysis, we’ve got you covered.

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Get in touch with our specialists to discuss your miRNA-seq project needs.